HRID2391584

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID587034

1-Chloro-2-(1-chloroethyl)benzene

C8H8Cl2

HCID68765327

未命名化合物

HCID68766294

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1sc(-n2cnc3cnccc32)cc1OC(C)c1ccccc1Cl

HCID68770215

未命名化合物

结构：COC(=O)c1sc(-n2cnc3ccncc32)cc1OC(C)c1ccccc1Cl

HCID68771752

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In a similar manner as described for example B3, 300 mg of an isomeric mixture of methyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate (example C1) and 181 mg K2CO3 and 206 mg 1-chloro-2-(1-chloroethyl)benzene in 5 ml N,N-dimethylformamide yield methyl 3-[1-(2-chlorophenyl)ethoxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and methyl 3-[1-(2-chlorophenyl)ethoxy]-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6cc1a026b5374f3e9d3757b5abf4d805
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273890B2
来源说明: uspto-grants-2012_09

反应 SMILES

[OH:1][C:2]1[CH:6]=[C:5]([N:7]2[C:15]3[CH:14]=[CH:13][N:12]=[CH:11][C:10]=3[N:9]=[CH:8]2)[S:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[OH:20][C:21]1[CH:25]=[C:24]([N:26]2[C:30]3[CH:31]=[N:32][CH:33]=[CH:34][C:29]=3[N:28]=[CH:27]2)[S:23][C:22]=1[C:35]([O:37][CH3:38])=[O:36].C([O-])([O-])=O.[K+].[K+].[Cl:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][C:47]=1[CH:52](Cl)[CH3:53]>CN(C)C=O>[Cl:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][C:47]=1[CH:52]([O:1][C:2]1[CH:6]=[C:5]([N:7]2[C:15]3[CH:14]=[CH:13][N:12]=[CH:11][C:10]=3[N:9]=[CH:8]2)[S:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17])[CH3:53].[Cl:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][C:47]=1[CH:52]([O:20][C:21]1[CH:25]=[C:24]([N:26]2[C:30]3[CH:31]=[N:32][CH:33]=[CH:34][C:29]=3[N:28]=[CH:27]2)[S:23][C:22]=1[C:35]([O:37][CH3:38])=[O:36])[CH3:53]