反应详情

In a similar manner as described for example B11, 81.7 mg of 1-(bromomethyl)-2-fluorobenzene, 100 mg of methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate, and 59.7 mg of potassium carbonate in 3 ml anhydrous DMF give methyl 3-[(2-fluorobenzyl)oxy]-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate as crude material that is used for step 2 without further purification.