Triethylamine → HCID 68764097, compound

HRID 2391658Notes

Reaction equation

HRID 2391658 reaction equation
[CH2:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[CH2:5][O:6][C:7]1[CH:11]=[C:10]([N:12]2[C:20]3[CH:19]=[C:18]([CH2:21]O)[N:17]=[CH:16][C:15]=3[N:14]=[CH:13]2)[S:9][C:8]=1[C:23]([NH2:25])=[O:24])[CH3:2].[CH3:30][S:31](Cl)(=[O:33])=[O:32].C(N(CC)CC)C>CN(C=O)C>[CH2:1]([C:3]1[CH:29]=[CH:28][CH:27]=[CH:26][C:4]=1[CH2:5][O:6][C:7]1[CH:11]=[C:10]([N:12]2[C:20]3[CH:19]=[C:18]([CH2:21][S:31]([CH3:30])(=[O:33])=[O:32])[N:17]=[CH:16][C:15]=3[N:14]=[CH:13]2)[S:9][C:8]=1[C:23]([NH2:25])=[O:24])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68771762HCID 68771762, compound

Product 1

HCID 68764097HCID 68764097, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described for example 49 (step 1), 210 mg of 3-[(2-ethylbenzyl)oxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 112 mg of methanesulfonyl chloride, and 104 mg of triethylamine in 5 ml DMF give 3-[(2-ethylbenzyl)oxy]-5-{6-[(methylsulfonyl)methyl]-1H-imidazo[4,5-c]pyridin-1-yl}thiophene-2-carboxamid as crude material that is used for step 2 without further purification.

Sources & evidence

ORD record
ord-5752fa1abb4b467888b760f10bac3886
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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