Hydrochloric Acid → 3-phenyl-6,7,8,9-tetrahydro-5H-1,2,7-triaza-benzocycloheptene dihydrochloride

HRID 239166Notes

Reaction equation

HRID 239166 reaction equation
[ClH:1].C(OC([N:9]1[CH2:15][CH2:14][C:13]2[N:16]=[N:17][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:19][C:12]=2[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[C:20]1([C:18]2[N:17]=[N:16][C:13]3[CH2:14][CH2:15][NH:9][CH2:10][CH2:11][C:12]=3[CH:19]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866860543-Phenyl-5,6,8,9-tetrahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester

Product 1

HCID 866860563-phenyl-6,7,8,9-tetrahydro-5H-1,2,7-triaza-benzocycloheptene dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

40 mL hydrogen chloride in dioxane was added to 5.5 g 3-phenyl-5,6,8,9-tetrahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester in 40 mL dioxane at 5° C. The reaction was stirred over night. The solvent was removed and co-evaporated with ethyl acetate to yield 3.7 g of the desired product. Rt: 4.09 min (method AE), (M+H)+: 226

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-686b6c0591da4b268d90df666ae98d26
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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