Hydrochloric Acid → Azepan-4-one hydrochloride

HRID 239168Notes

Reaction equation

HRID 239168 reaction equation
C(OC([CH:6]1[C:12](=[O:13])[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=O)C.[ClH:21]>>[ClH:21].[NH:9]1[CH2:8][CH2:7][CH2:6][C:12](=[O:13])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 44365701-tert-Butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate

Product 1

HCID 22021728Azepan-4-one hydrochloride

Procedure

20 g 5-Oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester was stirred over night at 110° C. in 200 mL 6 M hydrochloric acid. The reaction was concentrated to yield 11 g of the desired product. Rf: 0.20 (dichlormethane/methanol=9/1), (M+H)+=114

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-fe137c72a2694cdaa52050491cbc655d
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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