反应详情

In a similar manner as described for example B3, 7.92 g of an isomeric mixture of methyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate (example C1) and 4.77 g of K2CO3 and 8.23 g of 1-(bromomethyl)-2-(trifluoromethyl)benzene in 60 ml N,N-dimethylformamide yield compound B1a and compound B1b.

1. customyield compound B1a