Potassium Carbonate → HCID 68765176, compound

HRID 2391704Notes

Reaction equation

HRID 2391704 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH2:4]Br.[OH:11][C:12]1[CH:16]=[C:15]([N:17]2[C:21]3[CH:22]=[N:23][CH:24]=[CH:25][C:20]=3[N:19]=[CH:18]2)[S:14][C:13]=1[C:26]([O:28][CH3:29])=[O:27].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH2:4][O:11][C:12]1[CH:16]=[C:15]([N:17]2[C:21]3[CH:22]=[N:23][CH:24]=[CH:25][C:20]=3[N:19]=[CH:18]2)[S:14][C:13]=1[C:26]([O:28][CH3:29])=[O:27]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 301591-Bromomethyl-2,6-dichlorobenzeneHCID 68765327methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate

Product 1

HCID 68765176HCID 68765176, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described for example B11, 103.5 mg of 2,6-dichlorobenzyl bromide, 100 mg of methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate, 59.7 mg of potassium carbonate in 3 ml anhydrous DMF yield the title compound.

Sources & evidence

ORD record
ord-1fbe5ccb09e542ab9350275d82e0efd0
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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