2-Morpholinoethylamine → HCID 178523408, compound

HRID 2391741Notes

Reaction equation

HRID 2391741 reaction equation
CO[C:3]([C:5]1[N:10]=[CH:9][C:8]2[N:11]=[CH:12][NH:13][C:7]=2[CH:6]=1)=[O:4].[N:14]1([CH2:20][CH2:21][NH2:22])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>CO>[N:14]1([CH2:20][CH2:21][NH:22][C:3]([C:5]2[N:10]=[CH:9][C:8]3[N:11]=[CH:12][NH:13][C:7]=3[CH:6]=2)=[O:4])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 178497018HCID 178497018, compound

Product 1

HCID 178523408HCID 178523408, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 g of methyl-1H-imidazo[4,5-c]pyridine-6-carboxylate (example D2), 22.1 g of 2-morpholin-4-ylethanamine and 70 ml methanol were placed in an autoclave for 2 h at 140° C. The methanol and 2-morpholin-4-ylethanamine were distilled off the reaction mixture under reduced pressure and the residue was purified by flash chromatography. After crystallization from ethyl acetate/n-hexane the title compound was obtained.

Workup

  1. distillationThe methanol and 2-morpholin-4-ylethanamine were distilled off the reaction mixture under reduced pressure
  2. customthe residue was purified by flash chromatography
  3. customAfter crystallization from ethyl acetate/n-hexane the title compound
  4. customwas obtained

Sources & evidence

ORD record
ord-35acffd2cafc42578e25feb441b6838f
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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