反应详情

温度

120 °C

In 250 ml of N,N-dimethylformamide, 140 g of 4-methyl-4'-chlorodiphenylsulfone was dissolved, and further 77 g of thioglycolic acid and 71 g of 85% potassium hydroxide pellet were added and stirred for 6 hours at 120° C. The reaction mixture was poured into 2-propanol and filtered off to obtain a precipitate. After the precipitate obtained was dissolved in water and then the insoluble matter was filtered off, 150 ml of concentrated chloric acid and 500 g of ice were added therein. The formed white crystal was filtered off and washed with water and further recrystallized with a mixed solvent of n-hexane and ethylacetate to obtain 110 g of the intended 4-(4-methylphenylsulfonyl)phenylthio acetic acid.

1. filtrationfiltered off
2. customto obtain a precipitate
3. customAfter the precipitate obtained
4. filtrationthe insoluble matter was filtered off
5. addition150 ml of concentrated chloric acid and 500 g of ice were added
6. filtrationThe formed white crystal was filtered off
7. washwashed with water
8. customfurther recrystallized with a mixed solvent of n-hexane and ethylacetate