Potassium Bromide → HCID 18980387, compound

HRID 2392712Notes

Reaction equation

HRID 2392712 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[C:4]([N+:21]([O-:23])=O)[CH:3]=1.[K+].[Br-]>CCO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:10](=[O:20])[C:11]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)=[N+:21]2[O-:23]

Participants

4

Reactant 2

HCID 253877Potassium BromideHCID 67695988HCID 67695988, compound

Product 1

HCID 18980387HCID 18980387, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the general procedure described in Example 6 by substituting 8 mmol of 129 for 125. Yield: 91%; mp 238°-240° C. (from EtOH); IR (KBr) 3436, 3046, 2926, 2855, 1652, 1618, 1597, 1374, 1363 and 1263 cm-1 ; 1H NMR (in DMSO-d6) δ3.73 (s, 3H), 7.00 (m, 1H), 7.18 (m, 2H), 7.20 (s, 1H), 7.36 (m, 1H), 7.52 (s, 1H), 8.28 (s, 1H), 12.57 (br.s, 1H, N--H); HPLC: 100%; HRMS Calcd for C15H10N2O3Cl2 : 336.0068. Found: 336.0075.

Sources & evidence

ORD record
ord-227b25affa524d48afd4958418ecf5e3
Source dataset
uspto-grants-1998_09
Patent number
US05801183

Reaction notes

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