Potassium Bromide → HCID 18980367, compound

HRID 2392713Notes

Reaction equation

HRID 2392713 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10](=[O:20])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[C:4]([N+:21]([O-:23])=O)[CH:3]=1.[K+].[Br-]>CCO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:10](=[O:20])[C:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19])=[N+:21]2[O-:23]

Participants

4

Reactant 2

HCID 253877Potassium BromideHCID 67695601HCID 67695601, compound

Product 1

HCID 18980367HCID 18980367, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to the general procedure described in Example 6 by substituting 8 mmol of 131 for 125. Yield: 50%; mp 239°-241° C. (from EtOH); IR (KBr) 3459, 3050, 2958, 2796, 1651, 1618, 1375 and 1257 cm-1 ; 1H NMR (in DMSO-d6) δ3.69 (s, 3H), 7.00 (dd, 1H, JJ=7.4 Hz), 7.10 (d, 1H, J=7.4 Hz), 7.26 (d, 1H, J=7.4 Hz), 7.46 (dd, 1H, JJ=7.4 Hz), 7.54 (s, 1H), 8.26 (s, 1H), 12.58 (br.s, 1H, N--H); HPLC: 98%; HRMS Calcd for C15H10 N2O3Cl2 : 336.0068. Found: 336.0078.

Sources & evidence

ORD record
ord-ff42756d767741c49f4eaaf65c894773
Source dataset
uspto-grants-1998_09
Patent number
US05801183

Reaction notes

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