Formaldehyde → HCID 18980511, compound

HRID 2392740Notes

Reaction equation

HRID 2392740 reaction equation
[CH2:1]([O:4][CH:5]1[CH2:10][CH2:9][C:8](=[O:11])[CH2:7][CH2:6]1)[CH:2]=[CH2:3].[CH2:12]=O.[ClH:14].[CH3:15][NH:16][CH3:17]>C(O)(=O)C>[ClH:14].[CH2:1]([O:4][CH:5]1[CH2:10][CH2:9][C:8](=[O:11])[CH:7]([CH2:15][N:16]([CH3:12])[CH3:17])[CH2:6]1)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 184137294-(2-Propen-1-yloxy)cyclohexanone

Product 1

HCID 18980511HCID 18980511, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

15.5 g of compound (12) (100 mmole), 1.5 g (50 mmole) paraformaldehyde and 4.1 g (50 mmole) dimethylamine hydrochloride were stirred for 25 minutes in 30 ml acetic acid in a bath at 105° C. The acetic acid was distilled off under vacuum, and the residue was dissolved in 110 ml 2-butanone. Compound (13) was obtained in a yield of 77% theoretical, melting point 125° C.-127° C.

Workup

  1. distillationThe acetic acid was distilled off under vacuum
  2. dissolutionthe residue was dissolved in 110 ml 2-butanone

Sources & evidence

ORD record
ord-1795393f293147048d40a651f097c603
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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