Diisopropylethylamine → 4-Benzyl-2-cyano-1-phenylpiperazine

HRID 2393277Notes

Reaction equation

HRID 2393277 reaction equation
Cl.[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:19]([N:22](C(C)C)CC)(C)C.[C:28]([C:30](=C)C#N)#N>CN(C=O)C>[CH2:2]([N:9]1[CH2:30][CH2:28][N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]([C:19]#[N:22])[CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 136705Vinylidene cyanideHCID 12366334N1-Benzyl-N2-phenylethane-1,2-diamine hydrochloride

Product 1

HCID 149987524-Benzyl-2-cyano-1-phenylpiperazine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

A solution of 3 (5.07 g, 17.0 mmol) and diisopropylethylamine (4.97 g, 38.4 mmol) in DMF (40 mL) was treated with a solution of 2-cyanoacrylonitrile (2.30 g, 26.3 mmol) in DMF (40 mL) at room temperature (14 d). The solvent was removed in vacuo and the residue dissolved in dichloromethane and washed with water, brine, and dried (Na2SO4). Concentrated in vacuo, the residue was recrystallized from ethanol to afford 4 as white crystals.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. washwashed with water, brine
  4. dry with materialdried (Na2SO4)
  5. concentrationConcentrated in vacuo
  6. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-39fe6dfa71414307aa35e917ffdb40d5
Source dataset
uspto-grants-1998_09
Patent number
US05807856

Reaction notes

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