Water → HCID 18975607, compound

HRID 2393338Notes

Reaction equation

HRID 2393338 reaction equation
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[N:3]=1.[CH3:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:26][C:25](=[O:27])[CH:24]=[N:23]1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O.CCOCC>[CH3:14][C:4]1[N:5]=[C:6]([CH3:13])[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:2]([O:27][C:25]2[CH:24]=[N:23][N:22]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[CH3:15])[CH:26]=2)[N:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 18975621191657-82-6HCID 54017032HCID 54017032, compound

Product 1

HCID 18975607HCID 18975607, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of methyl (4-chloro-2,6-dimethyl-5-pyrimidinyl)-acetate (4.6 g, 21 mmol), 1-(2-methylphenyl)-1H-pyrazol-4-on (4.1 g, 23 mmol) and potassium carbonate (6.4 g, 46 mmol) in dimethylformamide (50 ml) is heated at +120° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-(2-methylphenyl)-1H-pyrazol4-yloxy)-pyrimidin-5-yl]-acetate as an oil.

Workup

  1. temperatureis heated at +120° C. for 2 hours
  2. customdrying

Sources & evidence

ORD record
ord-4c0eb44443e349be8e44dea0efe12d2a
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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