Hydrogen Peroxide → HCID 18975618, compound

HRID 2393341Notes

Reaction equation

HRID 2393341 reaction equation
OO.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[N:11]1[CH2:15][CH2:14][C:13](=[O:16])[NH:12]1.[Se](=O)=O.O>C(O)(=O)C>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[N:11]1[CH:15]=[CH:14][C:13](=[O:16])[NH:12]1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 24007Selenium DioxideHCID 18975619HCID 18975619, compound

Product 1

HCID 18975618HCID 18975618, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Hydrogen peroxide (30% solution in water, 120 ml) is slowly added to a well stirred suspension of 1-(2,5-dichlorophenyl)-3-pyrazolidone (200 g, 0.86 mol) and selenium dioxide (3.0 g) in acetic acid (1000 ml). The temperature is controlled by cooling, not to exceed +50° C. After stirring at this temperature for 1 hour crushed ice and water is added. The product is filtered and dried yielding 1-(2,5-dichlorophenyl)-3-pyrazolone, m.p. 201°-202° C.

Workup

  1. temperatureby cooling
  2. customto exceed +50° C
  3. stirringAfter stirring at this temperature for 1 hour
  4. additionis added
  5. filtrationThe product is filtered
  6. customdried

Sources & evidence

ORD record
ord-3fbcc38e111545ba88ab131c7a53ef2b
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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