Potassium Carbonate → HCID 18976540, compound

HRID 2393671Notes

Reaction equation

HRID 2393671 reaction equation
[CH3:1][N:2]1[CH2:8][C:6](=[O:7])[NH:5][C:3]1=[O:4].C(=O)([O-])[O-].[K+].[K+].[CH3:15][O:16][CH:17]([O:21][CH3:22])[CH2:18][CH2:19]Br>CS(C)=O>[CH3:15][O:16][CH:17]([O:21][CH3:22])[CH2:18][CH2:19][N:5]1[C:6](=[O:7])[CH2:8][N:2]([CH3:1])[C:3]1=[O:4]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 692171-MethylhydantoinHCID 1189323-Bromopropionaldehyde dimethylacetal

Product 1

HCID 18976540HCID 18976540, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
5 °C

Procedure

13.24 g (116 mmol) 1-methylhydantoin, 19.34 g (140 mmol) waterfree potassium carbonate and 29.2 g (3-bromo-propionaldehyd-dimethylacetal are allowed to react in 90 ml dimethylsulfoxid for 3 hours and 25 minutes at 112°-115° C. The reaction mixture is subsequently cooled to 5° C. and filtered with suction. The filtrate is evaporated in a rotary evaporator and the liquid crude product is purified by fractional distillation in vacuo to give 12.44 g (49.6% of theory) liquid 3-(3,3-dimethoxy-propyl)-1-methyl-imidazolidin-2,4-dione, having a boiling point of 112°-114° C./0.07 mbar.

Workup

  1. filtrationfiltered with suction
  2. customThe filtrate is evaporated in a rotary evaporator
  3. distillationthe liquid crude product is purified by fractional distillation in vacuo

Sources & evidence

ORD record
ord-6c80c37aff5e4e989eff55a27cd4a687
Source dataset
uspto-grants-1998_09
Patent number
US05807927

Reaction notes

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