Oxalyl chloride → HCID 10513791, compound

Temperature

0 °C

To a solution of 3-nitro-5-trifluoromethylbenzoic acid (0.36 g, 1.53 mmol) in CH2Cl2 (20 mL) was added oxalyl chloride (0.58 g, 4.60 mmol) followed by DMF (3 drops). An immediate evolution of gas occurred and the reaction was stirred for 18 h. The solvent was removed under reduced pressure, the resulting oil was dissolved in THF (80 mL) and cooled to 0° C. To the cooled solution was added EtOH (5 mL) in THF (15 mL) and the mixture was stirred for 18 h at room temperature. The mixture was concentrated to remove the THF and the resulting precipitate was filtered and dried. The solid was dissolved in EtOH (25 mL) and 10% Pd/C (0.12 g) was added and the suspension was stirred for 15 h under a blanket of H2. The reaction was filtered through celite and the filtrate evaporated to dryness to provide 3-ethoxycarbonyl-5-trifluoromethylaniline as a yellow oil. This compound was then coupled to 2-chloro-4-trifluoromethyl pyrimidine-5-carbonyl chloride as described above to provide the title compound in a 12% yield; m.p. 67°-71° C.

1. customThe solvent was removed under reduced pressure
2. dissolutionthe resulting oil was dissolved in THF (80 mL)
3. additionTo the cooled solution was added EtOH (5 mL) in THF (15 mL)
4. stirringthe mixture was stirred for 18 h at room temperature
5. concentrationThe mixture was concentrated
6. customto remove the THF
7. filtrationthe resulting precipitate was filtered
8. customdried
9. dissolutionThe solid was dissolved in EtOH (25 mL)
10. addition10% Pd/C (0.12 g) was added
11. stirringthe suspension was stirred for 15 h under a blanket of H2
12. filtrationThe reaction was filtered through celite
13. customthe filtrate evaporated to dryness

ORD record

ord-7e208bacfac54463b9a56a9d2c3da936

Source dataset

uspto-grants-1998_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05811428