Potassium Carbonate → HCID 15152395, compound

HRID 2394281Notes

Reaction equation

HRID 2394281 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:9]([O:11]C)=[O:10])=[N:6][C:7]=1[CH3:8].C([O-])([O-])=O.[K+].[K+]>O>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:9]([OH:11])=[O:10])=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 12619146Methyl 5-chloro-6-methylpyrazine-2-carboxylate

Product 1

HCID 15152395HCID 15152395, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of methyl 5-chloro-6-methyl-2-pyrazine carboxylate (0.16 g, 0.86 mmol), K2CO3 (0.31 g, 2.18 mmol) and H2O was stirred for 2 h at room temperature. The reaction was filtered and acidified (20% HCl), and the resulting solid collected to provide the title compound (0.057 g, 39% yield); m.p. 116°-117° C.

Workup

  1. filtrationThe reaction was filtered
  2. customthe resulting solid collected

Sources & evidence

ORD record
ord-e92157a3c8034bb987e920aa60e19fa5
Source dataset
uspto-grants-1998_09
Patent number
US05811428

Reaction notes

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