Potassium Carbonate → HCID 86753124, compound

HRID 2394293Notes

Reaction equation

HRID 2394293 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:17][C@@H:18]2[CH2:20][C@@H:19]2[F:21])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[CH:6][N:5]=[C:4]([Cl:22])[C:3]=1[Cl:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:22][C:4]1[C:3]([Cl:23])=[C:2]2[C:7]([C:8](=[O:9])[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][N:17]2[C@@H:18]2[CH2:20][C@@H:19]2[F:21])=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178472048HCID 178472048, compound

Product 1

HCID 86753124HCID 86753124, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6.6 g (0.017 mol) of ethyl 2-(4,5,6-trichloronicotinoyl)-3-[(1R,2S)-2-fluorocyclopropyl]aminoacrylate are stirred with 2.7 g (0.019 mol) of potassium carbonate in 35 ml of DMF at room temperature overnight. Ice-water is added to the mixture and the product is isolated.

Workup

  1. customthe product is isolated

Sources & evidence

ORD record
ord-a382b229cd344680b2297a165d351ee2
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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