Potassium Carbonate → HCID 56995839, compound

HRID 2394294Notes

Reaction equation

HRID 2394294 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:17][CH:18]([CH3:21])[CH2:19][OH:20])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[CH:6][N:5]=[C:4]([Cl:22])[C:3]=1[Cl:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:22][C:4]1[C:3]([Cl:23])=[C:2]2[C:7]([C:8](=[O:9])[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][N:17]2[CH:18]([CH3:21])[CH2:19][OH:20])=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178472013HCID 178472013, compound

Product 1

HCID 56995839HCID 56995839, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.2 g (0.014 mol) of ethyl 2-(4,5,6-trichloronicotinoyl)-3-(1-hydroxy-2-propyl)amino-acrylate are stirred with 2.3 g (0.0167 mol) of potassium carbonate in 28 ml of DMF at room temperature overnight. Ice-water is added to the mixture and the product is isolated. The mother liquor is extracted with chloroform and the organic phase is concentrated on a rotary evaporator. The crude products are stirred up with acetonitrile.

Workup

  1. customthe product is isolated
  2. extractionThe mother liquor is extracted with chloroform
  3. concentrationthe organic phase is concentrated on a rotary evaporator

Sources & evidence

ORD record
ord-a8d9424c56ef41b18fd759ce62f55a4b
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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