Potassium Carbonate → HCID 18973179, compound

HRID 2394295Notes

Reaction equation

HRID 2394295 reaction equation
[Cl:1][C:2]1[C:11](Cl)=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:8][N:9]2[CH:13]([CH3:16])[CH2:14][OH:15])=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[C:11]2=[C:10]3[C:5]([C:6](=[O:22])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:8][N:9]3[CH:13]([CH3:16])[CH2:14][O:15]2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 56995839HCID 56995839, compound

Product 1

HCID 18973179HCID 18973179, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.42 g (0.007 mol) of ethyl 7,8-dichloro-1-(1-hydroxy-2-propyl)-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate are heated with 1.15 g (0.0083 mol) of potassium carbonate in 14 ml of dimethylformamide at 80° C. for one hour. After addition of ice-water the precipitated product is isolated. The crude product is purified by column chromatography (eluent: dichloromethane/methanol 98:2).

Workup

  1. customis isolated
  2. customThe crude product is purified by column chromatography (eluent: dichloromethane/methanol 98:2)

Sources & evidence

ORD record
ord-39e80e91ed84447fa1b22036f3210660
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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