Potassium Carbonate → HCID 18973141, compound

HRID 2394297Notes

Reaction equation

HRID 2394297 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=2[F:25])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[CH:6][N:5]=[C:4]([Cl:26])[C:3]=1[F:27].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:26][C:4]1[C:3]([F:27])=[C:2]2[C:7]([C:8](=[O:9])[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][N:17]2[C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=2[F:25])=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178471934HCID 178471934, compound

Product 1

HCID 18973141HCID 18973141, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.26 g (10 mmol) of ethyl 2-(4,6-dichloro-5-fluoronicotinoyl)-3-(2,4-difluorophenyl)amino-acrylate are stirred with 1.65 g (12 mmol) of potassium carbonate in 28 ml of DMF at 100° C. for four hours. Ice-water is added to the mixture and the product is isolated.

Workup

  1. customthe product is isolated

Sources & evidence

ORD record
ord-474d2bd140144117969edfbfd9f82487
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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