Potassium Carbonate → HCID 18973157, compound

HRID 2394303Notes

Reaction equation

HRID 2394303 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:17][CH:18]2[CH2:20][CH2:19]2)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([CH3:21])[N:5]=[C:4]([Cl:22])[C:3]=1[Cl:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:22][C:4]1[C:3]([Cl:23])=[C:2]2[C:7]([C:8](=[O:9])[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][N:17]2[CH:18]2[CH2:20][CH2:19]2)=[C:6]([CH3:21])[N:5]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178471884HCID 178471884, compound

Product 1

HCID 18973157HCID 18973157, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.8 g (0.01 mol) of ethyl 2-(4,5,6-trichloro-2-methyl-nicotinoyl)-3-cyclopropylamino-acrylate are heated with 2.2 g (0.016 mol) of potassium carbonate in 40 ml of DMF at 100° C. for four hours. Ice-water is added to the cooled mixture and the product is isolated, washed with ice-water and dried.

Workup

  1. customthe product is isolated
  2. washwashed with ice-water
  3. customdried

Sources & evidence

ORD record
ord-5a0a2c43b64f46f8a83ee8ff84056d77
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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