2-Aminopropanol → HCID 18972739, compound

2.0 g of 2-amino-1-propanol was added dropwise to a stirred mixture of 1.3 g of 60% sodium hydride and 30 ml of N,N-dimethylformamide at room temperature. After the reaction mixture was stirred for 30 minutes, a solution containing 3.7 g of 2-chloropyrimidine dissolved in N,N-dimethylformamide was added dropwise to the reaction mixture. The mixture was stirred for 2 hours at 100° C. After completion of the reaction, the reaction mixture was cooled. The solids in the reaction mixture were filtered off. The solvent in the filtrate was removed under reduced pressure. The residue was purified by column chromatography on silica gel to obtain 2.1 g of the desired product (yield: 50%).

1. additionwas added dropwise to the reaction mixture
2. stirringThe mixture was stirred for 2 hours at 100° C
3. customAfter completion of the reaction
4. temperaturethe reaction mixture was cooled
5. filtrationThe solids in the reaction mixture were filtered off
6. customThe solvent in the filtrate was removed under reduced pressure
7. customThe residue was purified by column chromatography on silica gel

ORD record

ord-82b9570906404793b3087a9e9c346c73

Source dataset

uspto-grants-1998_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05811424