Trimethylsilylacetylene → HCID 18629998, compound

HRID 2394913Notes

Reaction equation

HRID 2394913 reaction equation
[Cl:1][C:2]1[C:12](I)=[CH:11][CH:10]=[C:9]([Si:14]([CH3:17])([CH3:16])[CH3:15])[C:3]=1[C:4]([NH:6][CH2:7][CH3:8])=[O:5].[CH3:18][Si:19]([C:22]#[CH:23])([CH3:21])[CH3:20]>C(N(CC)CC)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Cl:1][C:2]1[C:12]([C:23]#[C:22][Si:19]([CH3:21])([CH3:20])[CH3:18])=[CH:11][CH:10]=[C:9]([Si:14]([CH3:17])([CH3:16])[CH3:15])[C:3]=1[C:4]([NH:6][CH2:7][CH3:8])=[O:5]

Participants

5

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 10523923HCID 10523923, compound

Product 1

HCID 18629998HCID 18629998, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 8471TriethylamineSolvent

Procedure

To a slurry of the compound of Example 239 (0.763 g, 2.0 mmol), bis(triphenylphosphine)palladium dichloride (28 mg, 0.04 mmol) and cuprous iodide (15 mg, 0.08 mmol) in anhydrous triethylamine (10 mL) was added trimethylsilylacetylene (0.236 g, 2.4 mmol). The brown slurry was stirred at RT for 3.5 h, concentrated, slurried in ether and filtered through silica gel (ether). The crude product was further purified by flash chromatography (ethyl acetate/hexanes) followed by recrystallization from hexanes to afford the title compound as white crystals (0.618 g, 88%). m.p. 131°-132° C.

Workup

  1. concentrationconcentrated
  2. filtrationfiltered through silica gel (ether)
  3. customThe crude product was further purified by flash chromatography (ethyl acetate/hexanes)
  4. customfollowed by recrystallization from hexanes

Sources & evidence

ORD record
ord-6a1132f774bf4a23a96db011fcc55dae
Source dataset
uspto-grants-1998_09
Patent number
US05811411

Reaction notes

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