反应详情

温度

80 °C

1-t-Butoxycarbonyl-4-piperidinol (5.0 g 24.88 mmol) in dry dimethylformamide (60 ml) was treated with sodium hydride (60% 2.99 g 74.75 mmol) at room temperature under argon and then with 2-chloropyridine hydrochloride (4.1 g 27.33 mmol). Then mixture was heated at 80° C. overnight. After cooling the reaction was carefully quenched with water (5 ml) and then diluted with more water (20 ml) and extracted with ethyl acetate (30 ml). The organic solution was washed with sat. sodium bicarbonate, dried (MgSO4) and evaporated to give 1-t-butoxycarbonyl-4-(2-pyridoxy)piperidine (4.96 g 72%).

1. temperatureAfter cooling the reaction
2. customwas carefully quenched with water (5 ml)
3. additiondiluted with more water (20 ml)
4. extractionextracted with ethyl acetate (30 ml)
5. washThe organic solution was washed with sat. sodium bicarbonate
6. dry with materialdried (MgSO4)
7. customevaporated