1-Phenylpiperazine → HCID 86753178, compound

HRID 2395264Notes

Reaction equation

HRID 2395264 reaction equation
[Br-:1].Cl[CH2:3][CH2:4][C:5]([NH:7][C:8]1[CH:33]=[CH:32][CH:31]=[CH:30][C:9]=1[CH2:10][P+:11]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:6].[CH:34]1[CH:35]=[CH:36][C:37]([N:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[CH:38][CH:39]=1>C(#N)C>[Br-:1].[C:37]1([N:40]2[CH2:45][CH2:44][N:43]([CH2:3][CH2:4][C:5]([NH:7][C:8]3[CH:33]=[CH:32][CH:31]=[CH:30][C:9]=3[CH2:10][P+:11]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:6])[CH2:42][CH2:41]2)[CH:38]=[CH:39][CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 18971623HCID 18971623, compound

Product 1

HCID 86753178HCID 86753178, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-(3-chloropropionylamino)benzyltriphenylphosphonium bromide (2.70 g, 5 mmol) and phenylpiperazine (1.70 g, 10 mmol) in acetonitrile (85 ml) was heated at reflux for 2.5 h. The mixture was cooled to room temperature and filtered and the filtrate evaporated in vacuo to give 2-(3-[4-phenylpiperazin-1-yl]propionylamino) benzyltriphenylphosphonium bromide as a white solid (3.1 g, 93%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. filtrationfiltered
  4. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-72311338d0b24e1caf477217a2da7c3a
Source dataset
uspto-grants-1998_09
Patent number
US05814644

Reaction notes

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