反应详情

A solution of lithium hydroxide (346 mg, 8.25 mmol) in water (2 ml) was added to methyl indole-2-acetate (520 mg, 2.75 mmol) (prepared using the method of Capuano et al, Chem. Ber., 1986, 119, 2069) in THF (2 ml) and methanol (6 ml) and the mixture stirred for 1 h. The mixture was concentrated in vacuo, diluted with water (20 ml) and extracted with diethyl ether (2×10 ml). The aqueous layer was carefully acidified to pH 2 with 1M HCl and extracted into dichloromethane (3×20 ml). The extracts were dried (MgSO4) and evaporated in vacuo to give indole-2-acetic acid (350 mg, 72%) as a pink solid.

1. customprepared
2. concentrationThe mixture was concentrated in vacuo
3. additiondiluted with water (20 ml)
4. extractionextracted with diethyl ether (2×10 ml)
5. extractionextracted into dichloromethane (3×20 ml)
6. dry with materialThe extracts were dried (MgSO4)
7. customevaporated in vacuo