反应详情

(Deprotection Method A) Trifluoroacetic acid was added to a stirring suspension of (R)-N-[2-(4-methoxybenzoylamino)-2-phenylethyl]-1-tert-butoxycarbonylpiperidine-4-carboxamide (2.0 g, 4.2 mmol), methylene chloride (20 mL), and anisole (0.5 g, 4.6 mmol) at room temperature. A solution was obtained and bubbling was observed. After 1 h, the reaction mixture was evaporated at 40° C. The residue was taken up in warm methanol, and to this stirring solution was added ether to precipitate the product. The precipitate was collected by vacuum filtration, washed with ethyl acetate, then dried under vacuum at 60° C. overnight to afford 1.9 g (92%) of a white solid

1. customA solution was obtained
2. custombubbling
3. customthe reaction mixture was evaporated at 40° C
4. additionto this stirring solution was added ether
5. customto precipitate the product
6. filtrationThe precipitate was collected by vacuum filtration
7. washwashed with ethyl acetate
8. customdried under vacuum at 60° C. overnight