Hydrochloric Acid → 3-Amino-4-phenyl-2-butanone hydrochloride (1:1)

HRID 2395701Notes

Reaction equation

HRID 2395701 reaction equation
C([NH:4][CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6](=[O:8])[CH3:7])(=O)C.[ClH:16]>C(O)C>[ClH:16].[NH2:4][CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6](=[O:8])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 227936Acetamide, N-[2-oxo-1-(phenylmethyl)propyl]-

Product 1

HCID 133422503-Amino-4-phenyl-2-butanone hydrochloride (1:1)Yield 81%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-acetylamino-4-phenyl-2-butanone (12.5 g), 6N HCl (50 ml) and ethanol (50 ml) was stirred under refluxing conditions for 18 hours. The reaction mixture was concentrated under reduced pressure to yield 3-amino-4-phenyl-2-butanone hydrochloride (9.8 g, 81%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c78edbd5751a4a8eba828c8a9ca9e654
Source dataset
uspto-grants-1996_02
Patent number
US05489602

Reaction notes

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