反应详情

A mixture of veratrole (1,3-dimethoxybenzene) (13.8 g), 2-bromoisobutyryl bromide (23.0 g) and aluminium chloride (14.0 g) was heated for 1 hour at 70°-80° C. After cooling, ice and hydrochloric acid were added to the reaction mixture which was then extracted with ether. The extract was washed first with water and then with 1N NaOH-solution, dried and the solvent evaporated in vacuo, yielding a pale yellow oil (12.3 g).

1. temperaturewas heated for 1 hour at 70°-80° C
2. temperatureAfter cooling
3. extractionwas then extracted with ether
4. washThe extract was washed first with water
5. dry with materialwith 1N NaOH-solution, dried
6. customthe solvent evaporated in vacuo