5-Fluoroindole-2-carboxylic acid → 5-Fluoro-1H-indole-2-carbonyl chloride

HRID 2395740Notes

Reaction equation

HRID 2395740 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.C(Cl)(=O)C([Cl:17])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([Cl:17])=[O:13])=[CH:5]2

Participants

3

Reactant 2

HCID 18205-Fluoroindole-2-carboxylic acidHCID 65578Oxalyl chloride

Product 1

HCID 151678065-Fluoro-1H-indole-2-carbonyl chloride

Procedure

5-Fluorindole-2-carboxylic acid is dissolved in oxalylchloride and stirred 24 hr at 20°-25° in the dark. The reaction mixture is concentrated under reduced pressure to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-eb4360aaf731474cbf13c28d395eb167
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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