HRID2395875

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

HCID11430

Potassium Carbonate

CK2O3

HCID87885

Propanoic acid, 2,2-dimethyl-, chloromethyl ester

C6H11ClO2

HCID516893

Potassium bicarbonate

CHKO3

结构：C=CCOC(=O)NC(=N)c1ccc(N2CC(OC)=C(c3ccc(CCC(=O)O)cc3)C2=O)cc1

HCID139627756

未命名化合物

PRODUCTS

生成物

结构：C=CCOC(=O)NC(=N)c1ccc(N2CC(OC)=C(c3ccc(CCC(=O)OCOC(=O)C(C)(C)C)cc3)C2=O)cc1

HCID145823946

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared by stirring a suspension of 1-[4-(allyloxycarbonyl-amidino)-phenyl]-3-[4-(2-carboxy-ethyl)-phenyl]-4-methoxy-3-pyrrolin-2-one, 2 equivalents of chloromethyl pivalate, 2 equivalents of potassium iodide, 2 equivalents of potassium hydrogen carbonate and 2 equivalents of potassium carbonate in dimethylformamide at ambient temperature for three days.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fc4e4877929a42d5bf8a768d9d8c9e40
来源数据集: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05489693
来源说明: uspto-grants-1996_02

反应 SMILES

[CH2:1]([O:4][C:5]([NH:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][C:19]([O:21][CH3:22])=[C:18]([C:23]3[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:25][CH:24]=3)[C:17]2=[O:34])=[CH:12][CH:11]=1)=[NH:9])=[O:6])[CH:2]=[CH2:3].[C:35]([O:41][CH2:42]Cl)(=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37].[I-].[K+].C(=O)([O-])O.[K+].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([O:4][C:5]([NH:7][C:8]([C:10]1[CH:11]=[CH:12][C:13]([N:16]2[CH2:20][C:19]([O:21][CH3:22])=[C:18]([C:23]3[CH:24]=[CH:25][C:26]([CH2:29][CH2:30][C:31]([O:33][CH2:42][O:41][C:35](=[O:40])[C:36]([CH3:39])([CH3:38])[CH3:37])=[O:32])=[CH:27][CH:28]=3)[C:17]2=[O:34])=[CH:14][CH:15]=1)=[NH:9])=[O:6])[CH:2]=[CH2:3]