HRID2395876

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

结构：C=CCOC(=O)NC(=N)c1ccc(N2CC(OC)=C(c3ccc(CCC(=O)OCOC(=O)C(C)(C)C)cc3)C2=O)cc1

HCID145823946

未命名化合物

PRODUCTS

生成物

结构：COC1=C(c2ccc(CCC(=O)OCOC(=O)C(C)(C)C)cc2)C(=O)N(c2ccc(C(=N)N)cc2)C1

HCID18991065

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared by dropwise addition of 1 equivalent of morpholine to 1-[4-(allyloxycarbonyl-amidino)-phenyl]-4-methoxy-3-[4-[2-[(pivaloyloxymethyl)-oxycarbonyl]ethyl]-phenyl]-3-pyrrolin-2-one and 0.1 equivalents of tetrakis-(triphenyl-phosphine)-palladium(O) in tetrahydrofuran under inert gas followed by 1 hours' stirring at ambient temperature.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf5ac2b57f5d42c18329d9ecffe49af4
来源数据集: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05489693
来源说明: uspto-grants-1996_02

反应 SMILES

N1CCOCC1.C(OC([NH:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:26][C:25]([O:27][CH3:28])=[C:24]([C:29]3[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][C:37]([O:39][CH2:40][O:41][C:42](=[O:47])[C:43]([CH3:46])([CH3:45])[CH3:44])=[O:38])=[CH:31][CH:30]=3)[C:23]2=[O:48])=[CH:18][CH:17]=1)=[NH:15])=O)C=C>O1CCCC1>[C:14]([C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH2:26][C:25]([O:27][CH3:28])=[C:24]([C:29]3[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][C:37]([O:39][CH2:40][O:41][C:42](=[O:47])[C:43]([CH3:44])([CH3:45])[CH3:46])=[O:38])=[CH:31][CH:30]=3)[C:23]2=[O:48])=[CH:20][CH:21]=1)(=[NH:13])[NH2:15]