Chlorine → 2-Chloroamino-5-trifluoromethylpyridine

HRID 2396316Notes

Reaction equation

HRID 2396316 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[Cl:12]Cl>>[Cl:12][NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:11])[F:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24526ChlorineHCID 7358622-Amino-5-(trifluoromethyl)pyridine

Product 1

HCID 189888542-Chloroamino-5-trifluoromethylpyridine

Procedure

The method according to claim 1, wherein 2-amino-5-trifluoromethylpyridine is reacted with chlorine to form 2-chloroamino-5-trifluoromethylpyridine, which is then subjected to a rearrangement reaction in the presence of at least one carboxylic acid selected from the group consisting of formic acid, acetic acid and propionic acid to obtain 2-amino-3-chloro-5-trifluoromethylpyridine.

Sources & evidence

ORD record
ord-7e816c801dcc447bb4138eda1642160d
Source dataset
uspto-grants-1996_02
Patent number
US05491239

Reaction notes

Loading…