Benzoyl chloride → HCID 21460684, compound

HRID 2396335Notes

Reaction equation

HRID 2396335 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([F:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[CH2:17](N(CC)CC)C.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(OCC)(=O)C>C(Cl)Cl>[CH2:17]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([F:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:24]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:31]

Participants

6

Reactant 4

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 21460686HCID 21460686, compound

Product 1

HCID 21460684HCID 21460684, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Suspend 3-Amino-2-carbethoxy-6-fluoroindole (1.1 eq) in methylene chloride and add triethylamine (1.1 eq). Add benzoyl chloride (1.1 eq) and stir for30 minutes at room temperature to produce a precipitate. Dilute the reaction with ethyl acetate, rinse with water, dry over magnesium sulfate,filter and concentrate in vacuo to yield the title compound (1.26 g).

Workup

  1. customto produce a precipitate
  2. additionDilute
  3. washrinse with water
  4. dry with materialdry over magnesium sulfate,filter
  5. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-e02f37de61fd462e905fa67171f0c91a
Source dataset
uspto-grants-1996_02
Patent number
US05491153

Reaction notes

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