HCID 56985223, compound → HCID 57220130, compound

HRID 2396671Notes

Reaction equation

HRID 2396671 reaction equation
COC1C=C(C=CC=1OC)C[N:7]1[C:13](=[O:14])[C@@H:12]2[C@H:8]1[C@H:9]([CH2:22][C:23](=[O:32])[CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[CH2:10][N:11]2[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>C(OCC)(=O)C>[O:14]=[C:13]1[C@@H:12]2[C@@H:8]([C@H:9]([CH2:22][C:23](=[O:32])[CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[CH2:10][N:11]2[C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])[NH:7]1

Participants

3

Reactant 1

HCID 56985223HCID 56985223, compound

Product 1

HCID 57220130HCID 57220130, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared in analogy to Example 1g) starting from t-butyl (1S,4R, 5R)-6-(3,4-dimethoxybenzyl)-7-oxo-4-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-2,6-diazabicyclo[3.2.0]heptane-2-carboxylate (25.7 g; 48 mmol). Yield: 12.7 g (69%) as a colourless solid. M.p. 89°-91° C. (ethyl acetate).

Workup

  1. customThis compound was prepared in analogy to Example 1g)

Sources & evidence

ORD record
ord-5a6462db6fd0450baacf671180b99fe6
Source dataset
uspto-grants-1996_02
Patent number
US05494666

Reaction notes

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