反应详情

A mixture of diethyl 2-aminoethylphosphonate (12.5 g), isonicotinic acid (10.2 g), 1-hydroxybenzotriazole (11.2 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (15.83 g) and dichloromethane (190 ml) was stirred at room temperature for 15 hours. The reaction mixture was washed with aqueous sodium bicarbonate and brine, dried over anhydrous magnesium sulfate, and evaporated in vacuo. The residue was chromatographed on silica gel (5% methanol-chloroform) to give 7.94 g of N-(2-diethoxyphosphorylethyl)-4-pyridinecarboxamide as an oil.

1. washThe reaction mixture was washed with aqueous sodium bicarbonate and brine
2. dry with materialdried over anhydrous magnesium sulfate
3. customevaporated in vacuo
4. customThe residue was chromatographed on silica gel (5% methanol-chloroform)