Hydrochloric Acid → HCID 14651274, compound

HRID 2396978Notes

Reaction equation

HRID 2396978 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[N:6]1[C:15]2[C:10](=[C:11]([CH3:19])[C:12]([F:18])=[C:13]([F:17])[C:14]=2[F:16])[C:9](=[O:20])[C:8]([C:21]([O:23]CC)=[O:22])=[CH:7]1.Cl>C(O)(=O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[N:6]1[C:15]2[C:10](=[C:11]([CH3:19])[C:12]([F:18])=[C:13]([F:17])[C:14]=2[F:16])[C:9](=[O:20])[C:8]([C:21]([OH:23])=[O:22])=[CH:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14651275HCID 14651275, compound

Product 1

HCID 14651274HCID 14651274, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Employing ethyl 1-(2-thienyl)-5-methyl-6,7,8-trifluoro-1,4-dihydro-4 -oxoquinoline-3-carboxylate (1.05 g), conc. hydrochloric acid (10 ml) and 90% acetic acid (40 ml), the procedure of Reference Example 23 is repeated to give 1-(2-thienyl)-5-methyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.93 g), as white powder, m.p. 221°-222.5° C.

Sources & evidence

ORD record
ord-eee98288a8a94589b44c55d6fbff7db7
Source dataset
uspto-grants-1996_02
Patent number
US05495020

Reaction notes

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