(1,1'-Biphenyl)-4-methanol → 1-(Fluoromethyl)-4-phenylbenzene

HRID 2397107Notes

Reaction equation

HRID 2397107 reaction equation
O=S(=O)(F)c1ccc(C(F)(F)F)cc1.OCc1ccc(-c2ccccc2)cc1>C1CCOC1.CN1CCCN2CCCN=C12>FCc1ccc(-c2ccccc2)cc1

Participants

5

Reactant 2

HCID 19186(1,1'-Biphenyl)-4-methanolHCID 858282354-(Trifluoromethyl)benzenesulfonyl fluoride

Product 1

HCID 860378541-(Fluoromethyl)-4-phenylbenzeneYield 36%

Reagents, catalysts & solvents 2

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 8028TetrahydrofuranSolvent2×

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-a7d18bbc11e74c8da5299b88cef3836c
Source dataset
Deoxyfluorination screen
Original link
View source

Reaction notes

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