(1,1'-Biphenyl)-4-methanol → 1-(Fluoromethyl)-4-phenylbenzene

HRID 2397108Notes

Reaction equation

HRID 2397108 reaction equation
O=S(=O)(F)c1ccc(C(F)(F)F)cc1.OCc1ccc(-c2ccccc2)cc1>C1CCOC1.CN(C)C(=NC(C)(C)C)N(C)C>FCc1ccc(-c2ccccc2)cc1

Participants

5

Reactant 2

HCID 19186(1,1'-Biphenyl)-4-methanolHCID 858282354-(Trifluoromethyl)benzenesulfonyl fluoride

Product 1

HCID 860378541-(Fluoromethyl)-4-phenylbenzeneYield 83%

Reagents, catalysts & solvents 2

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineReagentHCID 8028TetrahydrofuranSolvent2×

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-d67878c703d346319e9de002a25622e3
Source dataset
Deoxyfluorination screen
Original link
View source

Reaction notes

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