Potassium Iodide → HCID 12562517, compound

HRID 2397315Notes

Reaction equation

HRID 2397315 reaction equation
[I-].[K+].FC(F)(F)[C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15](CCl)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[C:9]=2[CH:27]=1.C1(N)CC1>O1CCCC1>[Cl:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:10]1[C:9]2[CH:27]=[CH:5][CH:6]=[CH:7][C:8]=2[N:14]2[CH:15]=[N:16][N:17]=[C:13]2[CH2:12][N:11]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 213307808-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 12562517HCID 12562517, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, potassium iodide and 8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 8-trifluoromethyl-1-(cyclopropylamino)methyl]-6(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-237a0258424c4edd91c4ac685664755e
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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