Cyclopropylamine → HCID 21437261, compound

HRID 2397320Notes

Reaction equation

HRID 2397320 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[C:22]([F:23])=[CH:21][CH:20]=[CH:19][C:18]=3[F:24])[C:6]=2[CH:25]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][NH:29][CH:26]4[CH2:28][CH2:27]4)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[C:18]([F:24])=[CH:19][CH:20]=[CH:21][C:22]=3[F:23])[C:6]=2[CH:25]=1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 20291813HCID 20291813, compound

Product 1

HCID 21437261HCID 21437261, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1,potassium iodide and 8-chloro-1-(chloromethyl)-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 8-chloro-1-[(cyclopropylamino)methyl]-6-(2,6-difluorophenyl)4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-1c6ccc73ccbe4c559ab8434766f1ec54
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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