Potassium Iodide → HCID 12562517, compound

HRID 2397336Notes

Reaction equation

HRID 2397336 reaction equation
FC(F)(F)[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13](CCl)=[N:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:7]=2[CH:25]=1.[I-].[K+].C(N)C=C>O1CCCC1>[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:8]1[C:7]2[CH:25]=[CH:3][CH:4]=[CH:5][C:6]=2[N:12]2[CH:13]=[N:14][N:15]=[C:11]2[CH2:10][N:9]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 7853AllylamineHCID 213307808-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 12562517HCID 12562517, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 31, 8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine, potassium iodide and allylamine in tetrahydrofuran are reacted to give 8-(trifluoromethyl)-1-(allylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-7f9ee47b4e104adb8e5abcf635ff4f28
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

Loading…