Potassium Iodide → HCID 21437279, compound

HRID 2397342Notes

Reaction equation

HRID 2397342 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[I-].[K+].[CH2:26]([NH2:29])[CH:27]=[CH2:28]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][NH:29][CH2:26][CH:27]=[CH2:28])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 7853AllylamineHCID 20291841HCID 20291841, compound

Product 1

HCID 21437279HCID 21437279, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 31, 8-bromo-1-(chloromethyl)- 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, potassium iodide and allylamine in tetrahydrofuran are reacted to give 8-bromo-1-[(allylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-9110a862394c4450a23d7d85682375a0
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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