Cyclohexylamine → 4-(3',4'-Dichloro-4-biphenylyl)-butyric acid

HRID 2397372Notes

Reaction equation

HRID 2397372 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].C1(N)CCCCC1>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 183641344-(3',4'-Dichloro-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 214379354-(3',4'-Dichloro-4-biphenylyl)-butyric acidYield 62%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared analogous to Example 1 from 4-(3',4'-dichloro-4-biphenylyl)-4-oxo-butyric acid. Yield: 62% of theory. Melting point of the cyclohexylamine salt: 167°-168° C. (from isopropanol).

Sources & evidence

ORD record
ord-dbdba719b760422a9c96a563df749ce8
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

Loading…