Cyclohexylamine → 4-(4'-Chloro-2'-methyl-4-biphenylyl)-butyric acid

HRID 2397384Notes

Reaction equation

HRID 2397384 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[C:4]([CH3:21])[CH:3]=1.C1(N)CCCCC1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[C:4]([CH3:21])[CH:3]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 214379704-(4'-Chloro-2'-methyl-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 214379664-(4'-Chloro-2'-methyl-4-biphenylyl)-butyric acidYield 76%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogous to Example 1 by reduction of 4-(4'-chloro-2'-methyl-4-biphenylyl)-4-oxo-butyric acid. Yield: 76%. Melting point of the cyclohexylamine salt: 145.5°-147° C. (from ethyl acetate).

Sources & evidence

ORD record
ord-4d5f13f088e94ec89b4b484caa0dc068
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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