Isobutylamine → HCID 21437945, compound

HRID 2397390Notes

Reaction equation

HRID 2397390 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=1.C1(N)CCCCC1.C(N)C(C)C.[Na]>C(O)C.C(O)(C)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([OH:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=1

Participants

8

Reactant 4

HCID 6558IsobutylamineHCID 7965CyclohexylamineHCID 5360545SodiumHCID 13758271HCID 13758271, compound

Product 1

HCID 21437945HCID 21437945, compoundYield 55%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

Prepared analogous to example 25 from 4-(2'-chloro-4-biphenylyl)-4-oxo-butyric acid. Yield: 55% of theory. Melting point of the cyclohexylamine salt: 157°-158° C. (from water); melting point of the isobutylamine salt: 131°-133° C. (from isopropanol); the sodium salt has a double melting point of 90°-95° C. and 130°-133° C. (from ethanol).

Sources & evidence

ORD record
ord-fce58c0436d64785a7a358dc03c82cc9
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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