Cyclohexylamine → HCID 21437914, compound

HRID 2397397Notes

Reaction equation

HRID 2397397 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1.C1(N)CCCCC1>C(O)(C)C>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([OH:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 183641244-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 21437914HCID 21437914, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Prepared analogous to Example 25 from 4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid. Yield: 69% of theory; m.p. of the cyclohexylamine salt: 165°-167° C. (from isopropanol).

Sources & evidence

ORD record
ord-e9e17355efed46dbb1bcd0a03d1b52df
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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