Methanol → HCID 21437948, compound

HRID 2397416Notes

Reaction equation

HRID 2397416 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1C(=O)CCC(O)=O)#[N:2].[CH:22]1(N)[CH2:27]CCCC1.[C:29]([O:32]CC)(=[O:31])[CH3:30].C[OH:36]>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:27]([OH:36])[CH2:22][CH2:30][C:29]([OH:32])=[O:31])=[CH:13][CH:14]=1)#[N:2]

Participants

5

Reactant 4

HCID 887MethanolHCID 7965CyclohexylamineHCID 8857Ethyl AcetateHCID 21437979HCID 21437979, compound

Product 1

HCID 21437948HCID 21437948, compoundYield 94%

Procedure

Prepared analogous to Example 25 from 4-(2'-cyanobiphenylyl)-4-oxo-butyric acid. Melting point of the cyclohexylamine salt: 167°-168° C. (from ethyl acetate by addition of 15% methanol). Yield: 94% of theory.

Sources & evidence

ORD record
ord-ae6108f7a16244d9a88182783a1febe6
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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